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会議資料 (135 ページ)
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| 出典情報 | 医療上の必要性の高い未承認薬・適応外薬検討会議（第66回 12／12）《厚生労働省》 |
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要望番号；IV-203
TABLE 183-4
Recommended Antituberculosis Treatment Regimen
a: Except for TB of central nervous system, bone, or joint, for which longer therapy should be used.
b: All drugs should be given daily.
c: The American Thoracic Society, the Centers for Disease Control and Prevention, and the Infectious Diseases
Society of America suggest that a 2-month continuation phase could be used in HIV-seronegative patients with
sputum smear-negative and culture-negative TB.
d:Rifapentine is given at the daily dose of 1200 mg.
e: It is considered non-severe: TB of peripheral lymph nodes, intrathoracic lymph node without air obstruction,
uncomplicated pleural effusion, or paucibacillary, noncavitary disease confined to one lobe of the lungs and
without a miliary pattern.
f:The 6-month regimen with pyrazinamide can probably be used safely during pregnancy and is recommended by
the WHO and the International Union Against Tuberculosis and Lung Disease. If pyrazinamide is not included
in the initial treatment regimen, the minimal duration of therapy is 9 months.
g: Linezolid is given at the dosage of 600 mg daily. This regimen may be used without moxifloxacin in case of
documented resistance to fluoroquinolones.
Abbreviations: B, bedaquiline; Cfz, clofazimine; D, delamanid; E, ethambutol; Eto, ethionamide; H, isoniazid; Hh,
high-dose isoniazid (900 mg); L, linezolid; Lfx, levofloxacin; M, moxifloxacin; MDR/RR-TB, multidrug-
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135 / 451
TABLE 183-4
Recommended Antituberculosis Treatment Regimen
a: Except for TB of central nervous system, bone, or joint, for which longer therapy should be used.
b: All drugs should be given daily.
c: The American Thoracic Society, the Centers for Disease Control and Prevention, and the Infectious Diseases
Society of America suggest that a 2-month continuation phase could be used in HIV-seronegative patients with
sputum smear-negative and culture-negative TB.
d:Rifapentine is given at the daily dose of 1200 mg.
e: It is considered non-severe: TB of peripheral lymph nodes, intrathoracic lymph node without air obstruction,
uncomplicated pleural effusion, or paucibacillary, noncavitary disease confined to one lobe of the lungs and
without a miliary pattern.
f:The 6-month regimen with pyrazinamide can probably be used safely during pregnancy and is recommended by
the WHO and the International Union Against Tuberculosis and Lung Disease. If pyrazinamide is not included
in the initial treatment regimen, the minimal duration of therapy is 9 months.
g: Linezolid is given at the dosage of 600 mg daily. This regimen may be used without moxifloxacin in case of
documented resistance to fluoroquinolones.
Abbreviations: B, bedaquiline; Cfz, clofazimine; D, delamanid; E, ethambutol; Eto, ethionamide; H, isoniazid; Hh,
high-dose isoniazid (900 mg); L, linezolid; Lfx, levofloxacin; M, moxifloxacin; MDR/RR-TB, multidrug-
81
135 / 451