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【参考資料２－２】抗微生物薬適正使用の手引き 第四版（案）医科・入院編 (53 ページ)
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抗微生物薬適正使用の手引き
第四版
医科・入院編
1
2
3
30. Molina J, et al. Study protocol for a randomized clinical trial to assess 7 versus 14-days
of treatment for Pseudomonas aeruginosa bloodstream infections (SHORTEN-2 trial).
PLoS One. 2022. 17(12):e0277333.
4
5
6
7
31. von Dach E, et al. Effect of C-Reactive Protein-Guided Antibiotic Treatment Duration, 7Day Treatment, or 14-Day Treatment on 30-Day Clinical Failure Rate in Patients With
Uncomplicated Gram-Negative Bacteremia: A Randomized Clinical Trial. JAMA. 2020.
323(21):2160-2169.
8
9
10
32. Yahav D, et al. Seven Versus 14 Days of Antibiotic Therapy for Uncomplicated Gramnegative Bacteremia: A Noninferiority Randomized Controlled Trial. Clin Infect Dis. 2019.
69(7):1091-1098.
11
12
33. Babich T, et al. Duration of Treatment for Pseudomonas aeruginosa Bacteremia: a
Retrospective Study. Infect Dis Ther. 2022. 11(4):1505-1519.
13
14
15
34. Bae M, et al. Short versus prolonged courses of antimicrobial therapy for patients with
uncomplicated Pseudomonas aeruginosa bloodstream infection: a retrospective study. J
Antimicrob Chemother. 2021. 77(1):223-228.
16
17
35. Fabre V, et al. Antibiotic Therapy for Pseudomonas aeruginosa Bloodstream Infections:
How Long Is Long Enough? Clin Infect Dis. 2019. 69(11):2011-2014.
18
19
20
21
36. Mo Y, et al. REGARD-VAP investigators. Individualised, short-course antibiotic treatment
versus usual long-course treatment for ventilator-associated pneumonia (REGARDVAP): a multicentre, individually randomised, open-label, non-inferiority trial. Lancet
Respir Med. 2024. 12(5):399-408.
22
23
24
37. Liu C, et al. Clinical practice guidelines by the infectious diseases society of america for
the treatment of methicillin-resistant Staphylococcus aureus infections in adults and
children. Clin Infect Dis. 2011. 52(3):e18-55.
25
26
27
38. Molina J, et al. Seven-versus 14-day course of antibiotics for the treatment of
bloodstream infections by Enterobacterales: a randomized, controlled trial. Clin Microbiol
Infect. 2022. 28(4):550-557.
28
29
30
31
39. von Dach E, et al. Effect of C-Reactive Protein-Guided Antibiotic Treatment Duration, 7Day Treatment, or 14-Day Treatment on 30-Day Clinical Failure Rate in Patients With
Uncomplicated Gram-Negative Bacteremia: A Randomized Clinical Trial. JAMA. 2020.
323(21):2160-2169.
32
33
34
40. Yahav D, et al. Bacteremia Duration Study Group. Seven Versus 14 Days of Antibiotic
Therapy for Uncomplicated Gram-negative Bacteremia: A Noninferiority Randomized
Controlled Trial. Clin Infect Dis. 2019. 69(7):1091-1098.
35
36
37
41. Turjeman A, et al. Duration of antibiotic treatment for Gram-negative bacteremia Systematic review and individual participant data (IPD) meta-analysis.
EClinicalMedicine. 2023. 55:101750.
38
39
42. Roson B, et al. Causes and factors associated with early failure in hospitalized patients
with community-acquired pneumonia. Arch Intern Med. 2004. 164(5):502-508.
40
41
43. Ioanas M, et al. Causes and predictors of nonresponse to treatment of intensive care
unit-acquired pneumonia. Crit Care Med. 2004. 32(4):938-945.
42
43
44
44. Jang YR, et al. Prolonged fever is not a reason to change antibiotics among patients
with uncomplicated community-acquired acute pyelonephritis. Medicine (Baltimore).
2019. 98(43):e17720.
45
46
47
45. Hebeisen UP, et al. Catheter-related bloodstream infections with coagulase-negative
staphylococci: are antibiotics necessary if the catheter is removed? Antimicrob Resist
Infect Control. 2019. 8:21.
53
第四版
医科・入院編
1
2
3
30. Molina J, et al. Study protocol for a randomized clinical trial to assess 7 versus 14-days
of treatment for Pseudomonas aeruginosa bloodstream infections (SHORTEN-2 trial).
PLoS One. 2022. 17(12):e0277333.
4
5
6
7
31. von Dach E, et al. Effect of C-Reactive Protein-Guided Antibiotic Treatment Duration, 7Day Treatment, or 14-Day Treatment on 30-Day Clinical Failure Rate in Patients With
Uncomplicated Gram-Negative Bacteremia: A Randomized Clinical Trial. JAMA. 2020.
323(21):2160-2169.
8
9
10
32. Yahav D, et al. Seven Versus 14 Days of Antibiotic Therapy for Uncomplicated Gramnegative Bacteremia: A Noninferiority Randomized Controlled Trial. Clin Infect Dis. 2019.
69(7):1091-1098.
11
12
33. Babich T, et al. Duration of Treatment for Pseudomonas aeruginosa Bacteremia: a
Retrospective Study. Infect Dis Ther. 2022. 11(4):1505-1519.
13
14
15
34. Bae M, et al. Short versus prolonged courses of antimicrobial therapy for patients with
uncomplicated Pseudomonas aeruginosa bloodstream infection: a retrospective study. J
Antimicrob Chemother. 2021. 77(1):223-228.
16
17
35. Fabre V, et al. Antibiotic Therapy for Pseudomonas aeruginosa Bloodstream Infections:
How Long Is Long Enough? Clin Infect Dis. 2019. 69(11):2011-2014.
18
19
20
21
36. Mo Y, et al. REGARD-VAP investigators. Individualised, short-course antibiotic treatment
versus usual long-course treatment for ventilator-associated pneumonia (REGARDVAP): a multicentre, individually randomised, open-label, non-inferiority trial. Lancet
Respir Med. 2024. 12(5):399-408.
22
23
24
37. Liu C, et al. Clinical practice guidelines by the infectious diseases society of america for
the treatment of methicillin-resistant Staphylococcus aureus infections in adults and
children. Clin Infect Dis. 2011. 52(3):e18-55.
25
26
27
38. Molina J, et al. Seven-versus 14-day course of antibiotics for the treatment of
bloodstream infections by Enterobacterales: a randomized, controlled trial. Clin Microbiol
Infect. 2022. 28(4):550-557.
28
29
30
31
39. von Dach E, et al. Effect of C-Reactive Protein-Guided Antibiotic Treatment Duration, 7Day Treatment, or 14-Day Treatment on 30-Day Clinical Failure Rate in Patients With
Uncomplicated Gram-Negative Bacteremia: A Randomized Clinical Trial. JAMA. 2020.
323(21):2160-2169.
32
33
34
40. Yahav D, et al. Bacteremia Duration Study Group. Seven Versus 14 Days of Antibiotic
Therapy for Uncomplicated Gram-negative Bacteremia: A Noninferiority Randomized
Controlled Trial. Clin Infect Dis. 2019. 69(7):1091-1098.
35
36
37
41. Turjeman A, et al. Duration of antibiotic treatment for Gram-negative bacteremia Systematic review and individual participant data (IPD) meta-analysis.
EClinicalMedicine. 2023. 55:101750.
38
39
42. Roson B, et al. Causes and factors associated with early failure in hospitalized patients
with community-acquired pneumonia. Arch Intern Med. 2004. 164(5):502-508.
40
41
43. Ioanas M, et al. Causes and predictors of nonresponse to treatment of intensive care
unit-acquired pneumonia. Crit Care Med. 2004. 32(4):938-945.
42
43
44
44. Jang YR, et al. Prolonged fever is not a reason to change antibiotics among patients
with uncomplicated community-acquired acute pyelonephritis. Medicine (Baltimore).
2019. 98(43):e17720.
45
46
47
45. Hebeisen UP, et al. Catheter-related bloodstream infections with coagulase-negative
staphylococci: are antibiotics necessary if the catheter is removed? Antimicrob Resist
Infect Control. 2019. 8:21.
53