Figure 6. Monitoring on the sales volumes of antimicrobials

4) Collaboration with JANIS
Since FY2012, collaboration has been promoted between JVARM and JANIS (Japan Nosocomial Infections
Surveillance). The data of Escherichia coli derived from healthy animals collected under JVARM are converted into a
format comparable with JANIS data, and the results are published as antibiograms on the website of the National Veterinary
Assay Laboratory.[5] These data enable the comparison of trends in antimicrobial-resistant bacteria between humans and
animals.
Figure 7. Comparison of the proportion of third-generation cephalosporin-resistant Escherichia coli derived from
humans and those derived from food-producing animal

(Note)
Before 2015: From farms
From 2015: From animal and
poultry slaughterhouses
Humans

Broilers
Beef cattle

Pigs

The proportion of third-generation cephalosporin-resistant strains derived from humans and those derived from broilers
showed an increasing trend until 2011. The key factor behind this is thought to have been the suspension of off-label use
of third-generation cephalosporins by certain hatcheries following the presentation of JVARM data and guidance to
relevant groups, advising them to halt the use of these agents. On the other hand, the proportion still continues to rise in
humans, indicating different trends between humans and broilers.

95