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【参考資料２－４】抗微生物薬適正使用の手引き 第四版（案）歯科編 (29 ページ)
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抗微生物薬適正使用の手引き
第四版
歯科編
34. Alexander JW, et al. Updated recommendations for control of surgical site infections.
Ann Surg. 2011. 253:1082-93.
35. Nelson RL, et al. Antimicrobial prophylaxis for colorectal surgery. Cochrane Databas
Syst Rev. 2014. 5:CD001181.
36. Ren YF, et al. Effectiveness of antibiotic prophylaxis in third molar surgery: a metaanalysis of randomized controlled clinical trials. J Oral Maxillofac Surg. 2007. 65:190921.
37. Lodi G, et al. Antibiotics to prevent complications following tooth extractions. Cochrane
Database Syst Rev. 2021. 24; 2(2): CD003811.
38. Chiapasco M, et al. Side effects and complications associated with third molar surgery.
Oral Surg Oral Med Oral Pathol. 1993. 76:412–20.
39. Bui CH, et al. Types, frequencies, and risk factors for complications after third molar
extraction. J Oral Maxillofac Surg. 2003. 61:1379–89.
40. Sukegawa S, et al. What are the risk factors for postoperative infections of third molar
extraction surgery: a retrospective clinical study ? Med Oral Patol Oral Cir Bucal. 2019.
24(1): e123–e129.
41. Arteagoitia MI, et al. Efficacy of amoxicillin and amoxicillin/clavulanic acid in the
prevention of infection and dry socket after third molar extraction. A systematic review
and meta-analysis. Med Oral Patol Oral Cir Bucal. 2016. 21(4): e494-504.
42. Yoshida K, et al. Comparison between Single and Three Times Pre-operative
Administration of Amoxicillin in the Prophylactic Effects for Surgical Site Infections in
Japanese Patients with Mandibular Third Molars Extraction. Yakugaku Zasshi. 2022.
142(12):1391-1398.
43. Menon RK, et al. Does the use of amoxicillin/amoxicillin-clavulanic acid in third molar
surgery reduce the risk of postoperative infection? A systematic review with metaanalysis. Int J Oral Maxillofac Surg. 2019. 48(2):263-273.
44. Seidelman JL, et al. Surgical Site Infection Prevention: A Review. JAMA. 2023. 329(3).
244-252.
45. Esposito M, et al. Interventions for replacing missing teeth: antibiotics at dental implant
placement to prevent complications. Cochrane Database Syst Rev. 2013. 2013(7):
Cd004152.
46. 村上馨、他. 下顎埋伏智歯抜歯手術における術後感染予防抗菌薬に関する後方視的検討.
日化療会誌. 2019. 6(3)385-391.
47. Antimicrobial Prescribing in Dentistry: Good Practice Guidelines Chairside synopsis for
common conditions. https://cgdent.uk/antimicrobial-prescribing-in-dentistry/（2025 年 6
月 1 日アクセス）
48. Chrcanovic BR, et al. Prophylactic antibiotic regimen and dental implant failure: a metaanalysis. J Oral Rehabil. 2014. 41(12):941–56.
49. Park J, et al. Is there a consensus on antibiotic usage for dental implant placement in
healthy patients? Aust Dent J. 2018. 63(1):25-33.
50. Khouly I, et al. Antibiotic prophylaxis may not be indicated for prevention of dental
implant infections in healthy patients. A systematic review and meta-analysis. Clin Oral
Investig. 2019. 23(4):1525-1553.
51. Abd-Elwahab Radi I, et al. Which is the best antibiotic prophylaxis protocol to prevent
early implant failures? Evid Based Dent. 2019. 20(4):105-106.
29
第四版
歯科編
34. Alexander JW, et al. Updated recommendations for control of surgical site infections.
Ann Surg. 2011. 253:1082-93.
35. Nelson RL, et al. Antimicrobial prophylaxis for colorectal surgery. Cochrane Databas
Syst Rev. 2014. 5:CD001181.
36. Ren YF, et al. Effectiveness of antibiotic prophylaxis in third molar surgery: a metaanalysis of randomized controlled clinical trials. J Oral Maxillofac Surg. 2007. 65:190921.
37. Lodi G, et al. Antibiotics to prevent complications following tooth extractions. Cochrane
Database Syst Rev. 2021. 24; 2(2): CD003811.
38. Chiapasco M, et al. Side effects and complications associated with third molar surgery.
Oral Surg Oral Med Oral Pathol. 1993. 76:412–20.
39. Bui CH, et al. Types, frequencies, and risk factors for complications after third molar
extraction. J Oral Maxillofac Surg. 2003. 61:1379–89.
40. Sukegawa S, et al. What are the risk factors for postoperative infections of third molar
extraction surgery: a retrospective clinical study ? Med Oral Patol Oral Cir Bucal. 2019.
24(1): e123–e129.
41. Arteagoitia MI, et al. Efficacy of amoxicillin and amoxicillin/clavulanic acid in the
prevention of infection and dry socket after third molar extraction. A systematic review
and meta-analysis. Med Oral Patol Oral Cir Bucal. 2016. 21(4): e494-504.
42. Yoshida K, et al. Comparison between Single and Three Times Pre-operative
Administration of Amoxicillin in the Prophylactic Effects for Surgical Site Infections in
Japanese Patients with Mandibular Third Molars Extraction. Yakugaku Zasshi. 2022.
142(12):1391-1398.
43. Menon RK, et al. Does the use of amoxicillin/amoxicillin-clavulanic acid in third molar
surgery reduce the risk of postoperative infection? A systematic review with metaanalysis. Int J Oral Maxillofac Surg. 2019. 48(2):263-273.
44. Seidelman JL, et al. Surgical Site Infection Prevention: A Review. JAMA. 2023. 329(3).
244-252.
45. Esposito M, et al. Interventions for replacing missing teeth: antibiotics at dental implant
placement to prevent complications. Cochrane Database Syst Rev. 2013. 2013(7):
Cd004152.
46. 村上馨、他. 下顎埋伏智歯抜歯手術における術後感染予防抗菌薬に関する後方視的検討.
日化療会誌. 2019. 6(3)385-391.
47. Antimicrobial Prescribing in Dentistry: Good Practice Guidelines Chairside synopsis for
common conditions. https://cgdent.uk/antimicrobial-prescribing-in-dentistry/（2025 年 6
月 1 日アクセス）
48. Chrcanovic BR, et al. Prophylactic antibiotic regimen and dental implant failure: a metaanalysis. J Oral Rehabil. 2014. 41(12):941–56.
49. Park J, et al. Is there a consensus on antibiotic usage for dental implant placement in
healthy patients? Aust Dent J. 2018. 63(1):25-33.
50. Khouly I, et al. Antibiotic prophylaxis may not be indicated for prevention of dental
implant infections in healthy patients. A systematic review and meta-analysis. Clin Oral
Investig. 2019. 23(4):1525-1553.
51. Abd-Elwahab Radi I, et al. Which is the best antibiotic prophylaxis protocol to prevent
early implant failures? Evid Based Dent. 2019. 20(4):105-106.
29