よむ、つかう、まなぶ。
資料4-5 メトホルミン塩酸塩 (31 ページ)
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13） Johnson NP, et al. PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary
Syndrome evaluating Metformin for Infertility with Clomiphene. Hum Reprod. 2010; 25: 167583.
14） Karimzadeh MA, et al. An assessment of lifestyle modification versus medical treatment with
clomiphene citrate, metformin, and clomiphene citrate-metformin in patients with polycystic
ovary syndrome. Fertil Steril. 2010; 94: 216-20.
15） Tang T, et al. Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol)
for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane
Database Syst Rev. 2012; 5: Cd003053.
16） Legro RS, et al. Clomiphene, metformin, or both for infertility in the polycystic ovary
syndrome. N Engl J Med. 2007; 356: 551-66.
17） Zain MM, et al. Comparison of clomiphene citrate, metformin, or the combination of both for
first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with
polycystic ovary syndrome: a randomized controlled trial. Fertil Steril. 2009; 91: 514-21.
18） Moll E, et al. Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on
induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised
double blind clinical trial. BMJ. 2006; 332: 1485.
19） Moll E, et al. Does adding metformin to clomifene citrate lead to higher pregnancy rates in a
subset of women with polycystic ovary syndrome? Hum Reprod. 2008; 23: 1830-4.
20） Morin-Papunen L, et al. Metformin Improves Pregnancy and Live-Birth Rates in Women with
Polycystic Ovary Syndrome (PCOS): A Multicenter, Double-Blind, Placebo-Controlled
Randomized Trial. J Clin Endocrinol Metab. 2012; 97: 1492-500.
21） Hwu YM, et al. Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic
ovary syndrome. Int J Gynaecol Obstet. 2005; 90: 39-43.
22） Kocak M, et al. Metformin therapy improves ovulatory rates, cervical scores, and pregnancy
rates in clomiphene citrate-resistant women with polycystic ovary syndrome. Fertil Steril. 2002;
77: 101-6.
23） Creanga AA, et al. Use of metformin in polycystic ovary syndrome: a meta-analysis. Obstet
Gynecol. 2008; 111: 959-68.
24） Fertility problems: assessment and treatment. National Institute for Health and Care Excellence
clinical guideline; 2013. https://www.nice.org.uk/guidance/cg156/resources/fertility-problemsassessment-and-treatment-pdf-35109634660549（最終確認日：2022 年 1 月 18 日）
25） Palomba S, et al. Prospective parallel randomized, double-blind, double-dummy controlled
clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation
induction in nonobese anovulatory women with polycystic ovary syndrome, J Clin Endocrinol
Metab. 2005; 90; 4068-74.
26） Zain MM, et al. Comparison of clomiphene citrate, metformin, or the combination of both for
31
Syndrome evaluating Metformin for Infertility with Clomiphene. Hum Reprod. 2010; 25: 167583.
14） Karimzadeh MA, et al. An assessment of lifestyle modification versus medical treatment with
clomiphene citrate, metformin, and clomiphene citrate-metformin in patients with polycystic
ovary syndrome. Fertil Steril. 2010; 94: 216-20.
15） Tang T, et al. Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol)
for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane
Database Syst Rev. 2012; 5: Cd003053.
16） Legro RS, et al. Clomiphene, metformin, or both for infertility in the polycystic ovary
syndrome. N Engl J Med. 2007; 356: 551-66.
17） Zain MM, et al. Comparison of clomiphene citrate, metformin, or the combination of both for
first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with
polycystic ovary syndrome: a randomized controlled trial. Fertil Steril. 2009; 91: 514-21.
18） Moll E, et al. Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on
induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised
double blind clinical trial. BMJ. 2006; 332: 1485.
19） Moll E, et al. Does adding metformin to clomifene citrate lead to higher pregnancy rates in a
subset of women with polycystic ovary syndrome? Hum Reprod. 2008; 23: 1830-4.
20） Morin-Papunen L, et al. Metformin Improves Pregnancy and Live-Birth Rates in Women with
Polycystic Ovary Syndrome (PCOS): A Multicenter, Double-Blind, Placebo-Controlled
Randomized Trial. J Clin Endocrinol Metab. 2012; 97: 1492-500.
21） Hwu YM, et al. Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic
ovary syndrome. Int J Gynaecol Obstet. 2005; 90: 39-43.
22） Kocak M, et al. Metformin therapy improves ovulatory rates, cervical scores, and pregnancy
rates in clomiphene citrate-resistant women with polycystic ovary syndrome. Fertil Steril. 2002;
77: 101-6.
23） Creanga AA, et al. Use of metformin in polycystic ovary syndrome: a meta-analysis. Obstet
Gynecol. 2008; 111: 959-68.
24） Fertility problems: assessment and treatment. National Institute for Health and Care Excellence
clinical guideline; 2013. https://www.nice.org.uk/guidance/cg156/resources/fertility-problemsassessment-and-treatment-pdf-35109634660549（最終確認日：2022 年 1 月 18 日）
25） Palomba S, et al. Prospective parallel randomized, double-blind, double-dummy controlled
clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation
induction in nonobese anovulatory women with polycystic ovary syndrome, J Clin Endocrinol
Metab. 2005; 90; 4068-74.
26） Zain MM, et al. Comparison of clomiphene citrate, metformin, or the combination of both for
31