よむ、つかう、まなぶ。
医薬品の一般的名称について（令和8年4月20日医薬薬審発0420第1号） (12 ページ)
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| 公開元URL | https://www.mhlw.go.jp/hourei/doc/tsuchi/T260421I0010.pdf |
| 出典情報 | 医薬品の一般的名称について（4／20付 通知）《厚生労働省》 |
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Zeleciment Rostudirsen is an antibody-oligonucleotide-conjugate (molecular weight: ca. 71,000) consisting of
Rostudirsen (C421H655N192O136P30; molecular weight: 11,510) attached to an average of two lysine residues of the
recombinant monoclonal antibody. The antibody moiety is an Fab fragment of recombinant anti-transferrin receptor 1
monoclonal antibody whose complementarity-determining regions are derived from mouse antibody and other regions
are derived from human IgG1. In the H-chain, the amino acid residue is substituted at 1 position (L114T). The protein
moiety is produced in CHO cells and is composed of 1 H-chain (γ1-chain) consisting of 227 amino acid residues and
1 L-chain (κ-chain) consisting of 214 amino acid residues.
Rostudirsen (C421H655N192O136P30; molecular weight: 11,510) attached to an average of two lysine residues of the
recombinant monoclonal antibody. The antibody moiety is an Fab fragment of recombinant anti-transferrin receptor 1
monoclonal antibody whose complementarity-determining regions are derived from mouse antibody and other regions
are derived from human IgG1. In the H-chain, the amino acid residue is substituted at 1 position (L114T). The protein
moiety is produced in CHO cells and is composed of 1 H-chain (γ1-chain) consisting of 227 amino acid residues and
1 L-chain (κ-chain) consisting of 214 amino acid residues.